Gene Therapy for Ocular Disease
نویسندگان
چکیده
منابع مشابه
Gene therapy for PRPH2-associated ocular disease: challenges and prospects.
The peripherin-2 (PRPH2) gene encodes a photoreceptor-specific tetraspanin protein called peripherin-2/retinal degeneration slow (RDS), which is critical for the formation and maintenance of rod and cone outer segments. Over 90 different disease-causing mutations in PRPH2 have been identified, which cause a variety of forms of retinitis pigmentosa and macular degeneration. Given the disease bur...
متن کاملGene therapy for ocular angiogenesis.
Ocular neovascularization is a central feature of diabetic retinopathy and age-related macular degeneration. These conditions are the major causes of blindness in the developed world. Current treatments are of limited efficacy and associated with significant adverse effects. Characterization of the molecular and cellular events involved in angiogenesis has led to the identification of a number ...
متن کاملOcular gene therapy: quo vadis?
The question of where gene therapy is going has almost as many answers as there are practitioners in the field. Narrowing our focus to diseases of the eye, this diversity of opinions does not contract proportionately. Therefore, rather than forecasting the future, it is more useful to assess the field today, including a consideration of where problems remain before clinical trials would be gene...
متن کاملNanoparticle applications in ocular gene therapy
The use of nanoparticles as carriers for the delivery of therapeutic materials to target tissues has became popular in recent years and has demonstrated great potentials for the treatments of a wide range of diseases. In this review, we summarize the advantages of nanotechnology as a common gene delivery strategy with emphasis on ocular therapy. Particular attention is paid to the CK30-PEG comp...
متن کاملGene therapy for neurodegenerative and ocular diseases using lentiviral vectors.
Gene therapy holds great promise for the treatment of a wide range of inherited and acquired disorders. The development of viral vector systems to mediate safe and long-lasting expression of therapeutic transgenes in specific target cell populations is continually advancing. Gene therapy for the nervous system is particularly challenging due to the post-mitotic nature of neuronal cells and the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2000
ISSN: 1525-0016
DOI: 10.1006/mthe.2000.0080